New material projects have become the new darling of local industrial planning in recent years. Ningbo has taken the lead in this new wave of industrial development. Magnetic materials, polymer materials, nanomaterials, new energy materials, semiconductor materials, vehicle new materials and other industries Wind and water. Pyrimidine series intermediates
Pyrimidine, also known as 1,3-diazepine, is a heterocyclic compound with the chemical formula C4H4N2. Pyrimidine is formed by replacing 2 carbons in the meta-position of benzene with 2 nitrogen atoms, and is a diazine. Like pyridine, pyrimidine retains its aromaticity.
Introduction
Name: Pyrimidine
Molecular formula: C4H4N2
Molar mass: 80.09 g/mol
Density: 1.016 g/ml
Melting point: 20 - 22 °C
Boiling point: 123 - 124 °C
CAS Number: 289-95-2
EINECS Number: 206-026-0
SMILES: C1=NC=NC=C1
Application
(1) Anticancer drugs. In the selection of anticancer substances, it is crucial that there are significant differences between tumor tissues and normal tissues, that is, they have a certain ability to recognize target cells. Porphyrin compounds have special affinity for cancer cells due to their unique structures, and they can selectively stay in cancer tissues. The research of it as a localizing agent and a drug for diagnosis and treatment of cancer has already aroused great interest of chemists, medical scientists and biologists. 5-Fluorouracil is a widely used anti-metabolite and anti-tumor drug in clinic. It has inhibitory effect on various tumors. It has good clinical effect in the treatment of colorectal cancer, gastric cancer, breast cancer and other cancers. Polyesters, polyester hydrocarbons, polyester amides, deoxyribonucleic acid, furans, 5-fluorouracil derivatives linked to nitroxide radicals all have antitumor effects.
(2) Anti-AIDS drugs. Viral diseases have become one of the most harmful diseases to human beings, especially the spread of AIDS, which has aroused widespread concern. There are many kinds of anti-AIDS drugs that have been approved by the US Food Administration (FDA), many of which are nucleoside compounds. In order to reduce the toxicity of drugs and improve their efficacy, scientists have begun to turn their attention to the study of non-nucleoside compounds, and such compounds have become the focus of antiviral drug research.
Synthetic method
Pyrimidines and various substituted pyrimidines are synthesized in a variety of ways. For example, barbituric acid (2,4,6-trihydroxypyrimidine) can be obtained by the condensation of urea and diethyl malonate under the action of sodium alkoxide. Barbituric acid and phosphorus oxychloride are heated together to obtain 2,4,6-trichloropyrimidine, which reacts with sodium methoxide to obtain trimethoxypyrimidine. Chloropyrimidines react with ammonia or primary and secondary amines to generate the corresponding aminopyrimidines. The derivatives of pyrimidine, cytosine, uracil and thymine, are the constituent parts of nucleic acid and deoxynucleic acid, and the pyrimidine part in the vitamin B1 molecule is a 4-amino-2-methyl-5-pyrimidine methyl group. Many oral long-acting sulfa drugs are derivatives of pyrimidine and its isomers.
The 2,4-dichloropyrimidine is prepared by reduction reaction in the presence of palladium, magnesium oxide and activated carbon.
Pyrimidine Series Intermediates,2-Chloro-5-Methylpyrimidine,5-Bromo-2-chloropyrimidine,2 4-Dichloro-5-Methylpyrimidine Fuxin Custchem Fine Chemical Co., Ltd. , https://www.custchemvip.com
Ningbo Yunsheng (Group) Co., Ltd. is the world's largest music box manufacturer and supplier. In 1996, Ningbo Yunsheng Strong Magnetic Material Co., Ltd. was established and began to set foot in the field of new materials. Through continuous technological transformation, the scale of business operations has continued to expand, and many invention patents and utility model patents such as molds and castings for casting under magnetic fields have been obtained. Now it is the most important NdFeB production and sales base in China.
In 2001, the company signed a patent license agreement with Sumitomo Special Metals Co., Ltd. for the production and sale of sintered NdFeB, and became the legal manufacturer and seller of patents in North America and Europe. In recent years, the company has made full use of its advantages in precision machinery manufacturing and development of rare earth permanent magnetic materials, and has actively advanced into new energy motors, wind power and other industries, and realized the extension of the industrial chain. At present, Yunsheng has an annual production capacity of 1 million sets of automobile generators and 500,000 sets of automobile starters, while magnets required for hybrid electric vehicles and electric motors are used in high-tech NdFeB applications. Major expansion.
If Ningbo Yunsheng represents the local magnetic material industry, then Ningbo Dacheng New Material Co., Ltd. of Cixi is the leader of Ningbo's new textile material industry.
Starting from ordinary chemical fiber, Ningbo Dacheng relied on independent innovation and cooperation between production, learning and research, and successively completed eight national-level torch plans, three national-level high-tech development plans, two high-tech research and industrialization projects of the National Development and Reform Commission, and one national major science and technology. Research projects. In 1996, Dacheng Chemical began to study high-strength, high-modulus polyethylene fibers.
In the 1990s, this product was only produced by DSM Holland, Honeywell USA, and Mitsui Corporation of Japan, and was listed as "Paris Co-ordinated Products in the West". Its production process, technology, and products were applied to socialist countries. Embargo. After more than four years of hard work, Ningbo Dacheng spent a great deal of scientific research and finally solved problems. At the beginning of 2000, it successfully achieved industrialization, filled the domestic gap, and became the fourth highest in the world with independent intellectual property technology. , high-mode polyethylene fiber production enterprises. At present, the company has formed an annual output of 1,800 tons of production capacity, ranking second in the world. The products are exported to more than 50 countries and regions. It is the largest domestic and internationally influential bulletproof material manufacturer.
In addition, there is also the largest powder metallurgy machinery parts manufacturing company in Ningbo, Ningbo Dongxi New Materials Group Co., Ltd., the world's largest biodegradable resin production company Ningbo Tianan Biological Co., Ltd., the first domestic company with monocrystalline silicon, epitaxy, Ningbo Lili Electronics Co., Ltd., which is a complete industrial chain from film to polished film, is the third company in the world that has MDI independent intellectual property rights, Ningbo Wanhua. These new material companies occupy a pivotal position in their respective fields.
“Ask where the water is clear, but the source of living water comes.†Yang Bingjie, deputy director of the Industrial and High-tech Industry Development Division of Ningbo Municipal Development and Reform Commission, believes that if the development of Ningbo's new material industry is due to the market demand Sensitive, then the reason why the industry can flourish, its fundamental driving force is from the support of scientific and technological forces. "In the field of new materials, Ningbo has 2 state-level research institutes of the Ningbo Institute of Materials Science and Technology and the Ningbo Branch of the Chinese Academy of Sciences. Ningbo University, Ningbo Institute of Technology, Zhejiang Textile and Apparel Institute, Ningbo Chemical Research Institute and other research institutes have developed new materials technologies in recent years. The role of development has become increasingly apparent, and through the combination of production, education and research, scientific research institutes have formed close partnerships with local new material companies to solve problems in production, provide solutions for industrial development, and become a strong force for the healthy development of Ningbo's new material industry. backing.